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Daphne Pham
  • Daphne Pham, Ph. D.

  • Professor and Chair - Biological Sciences
  • Postdoctoral Fellow, Department of Biochemistry and Molecular Biophysics, University of Arizona,
  • Biological Sciences
  • (262) 595-2172
  • pham@uwp.edu
Biography
Professional Experience: Professor, University of Wisconsin-Parkside, Department of Biological Sciences Associate Professor, University of Wisconsin-Parkside, Department of Biological Sciences Assistant Professor, University of Wisconsin-Parkside, Department of Biological Sciences Research Assistant Professor, University of Arizona, Department of Biochemistry & Molecular Biophysics Education: Post-doctoral Fellow, University of Arizona, Department of Biochemistry & Molecular Biophysics Ph. D., Entomology, University of California, Riverside M. S., Chemistry, University of California, Riverside B. S., Chemistry, University of California, Davis
Teaching, Research/Creative & Consulting Interests

Teaching Interests

BIOS 100 (Nature of Life), BIOS 101 (Bioscience), BIOS 301 (Cell Biology), BIOS 390 (Forensic Science), BIOS 453/653 (Molecular Biology & Bioinformatics of Nucleic Acids)

Research Interests

RIBONUCLEOTIDE REDUCTASE. My long-term objective is to understand human disease transmission by blood-feeding insect vectors. I am specifically interested in the role that iron plays during pathogenic invasion. Data in vertebrates suggest that pathogenic infectivity may be linked to the availability of iron in the host. In vertebrates, some iron-binding proteins are upregulated under pathological conditions. This upregulation is hypothesized to cause chelation of iron and thus reduce iron availability to the pathogen. The actual machinery that activates this response remains unknown. My aim is to elucidate the mechanisms by which pathogenic infectivity is affected by the host iron metabolism. The host organism for my research is the hematophagous (blood feeding) mosquito, a vector of numerous diseases. Worldwide, millions of people die yearly from diseases transmitted by hematophagous insects. In the U.S., for the past few years, the West Nile virus carried by the mosquito Culex pipiens has caused epidemic outbreaks nationwide and cost the U. S. hundreds of thousands of dollars; West Nile virus is moving westward and southward. With all the public health concerns, not much is known about the basic biology of hematophagous insects. My work has a foundation for understanding how these disease vectors regulate their iron metabolism.

Consulting Interests

Medical Entomology; Biochemistry; Molecular Biology
Publications
Selected Publications

2017: Ferritin, Reference Module in Life Sciences (16 pp.)

2016: Ferritin, Reference Module in Life Sciences

: Prospective Cohort Study of Iron Indices in Term Neonates after Delayed Umbilical Cord Clamping, (19 pp.)

2014: Mosquito Ribonucleotide Reductase: A Site for Control, Short Views on Insect Biochemistry and Molecular Biology (449-472 pp.)

2014: Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African Trypanosomiasis , Science (380-6 pp.)

2013: Impact of Multiple Prenatal Risk Factors on Newborn Iron Status at Delivery, J Pediatr Hematol Oncol (473-77 pp.)

2010: Insect Ferritins: Atypical or Typical?, Biochim. Biophys. Acta (824–833 pp.)

2007: Implementation and Assessment of a Molecular Biology & Bioinformatics Undergraduate Degree Program, Biochemistry and Molecular Biology Education (102-115 pp.)

2006: Iron Metabolism in Insect Disease Vectors: Mining the Anopheles gambiae Database., Insect Biochem. Mol. Biol. (310-21 pp.)

2006: Regulation of the ribonucleotide reductase small subunit (R2) in the yellow fever mosquito, Aedes aegypti, Gene (182-90 pp.)

2005: Accumulation of lipids in insect oocytes., Reproductive Biology of Invertebrates. (265-287 pp.)

2005: Regulation of the ferritin heavy-chain homologue gene in the yellow fever mosquito, Aedes aegypti, Insect Mol. Biol. (223-36 pp.)

2005: The ferritin light-chain homologue promoter in Aedes aegypti., Insect Mol. Biol. (263-70 pp.)

2004: Ferritin, Comprehensive Insect Physiology, Biochemistry, Pharmacology and Molecular Biology. Elsevier (16 pp.)

2003: Aedes aegypti ferritin: a cytoxic protector?, Eur. J. Biochem (3667-74 pp.)

2003: Identification and mapping of the promoter for the gene encolding the heavy chain homologue of the yellow fever mosquito Aedes aegyptin, Insect Biochem. Mol. Biol (51-62 pp.)

Selected Awards & Honors

Teaching Awards

2013: Wisconsin Teaching Fellows and Scholars are selected from among the University of Wisconsin System faculty and academic staff on the merit of their outstanding teaching., 2014-15 Wisconsin Teaching Scholar, UW System

Research/Creative Awards

2004: Excellence in Research & Creative Activity Award , UWP
2002: University of Wisconsin System Researcher Recognition, Governor
Key Service Activities

Departmental Service

2013: Other - DNA Day: HS Recruitment

College Service

2014: Session Chair - Big Read
2014: Committee Chair - Science Night
2013: Committee Chair - DNA Day
2013: Committee Chair - Science Night
2012: Committee Chair - DNA Day
2012: Committee Chair - Science Night
2011: Committee Chair - Science Night

University Service

2016: Committee Member - University Committee
2013: Committee Chair - University Committee
Courses Taught

Spring 2018

BIOS 453 MOL BIO/BIOINFRM NUCLEIC ACIDS
BIOS 653 MOL BIO/BIOINFRM NUCLEIC ACIDS
BIOS 495 SENIOR SEMINAR
BIOS 495 SENIOR SEMINAR

Fall 2017

BIOS 101 BIOSCIENCE
BIOS 499 INDEPENDENT STUDY
BIOS 489 MOLEC BIO/BIOINFRM SR PROJECT
BIOS 731 SEMINAR IN MOLECULAR BIOLOGY
BIOS 495 SENIOR SEMINAR
BIOS 495 SENIOR SEMINAR
BIOS 711 THESIS

Spring 2017

BIOS 301 CELL BIOLOGY
BIOS 301 CELL BIOLOGY
BIOS 499 INDEPENDENT STUDY
BIOS 489 MOLEC BIO/BIOINFRM SR PROJECT
BIOS 100 NATURE OF LIFE
BIOS 731 SEMINAR IN MOLECULAR BIOLOGY
BIOS 711 THESIS

Fall 2016

BIOS 499 INDEPENDENT STUDY
BIOS 453 MOL BIO/BIOINFRM NUCLEIC ACIDS
BIOS 653 MOL BIO/BIOINFRM NUCLEIC ACIDS
BIOS 711 THESIS

Summer 2016

BIOS 301 CELL BIOLOGY

Spring 2016

BIOS 101 BIOSCIENCE
BIOS 499 INDEPENDENT STUDY
BIOS 489 MOLEC BIO/BIOINFRM SR PROJECT
BIOS 489 MOLEC BIO/BIOINFRM SR PROJECT
BIOS 100 NATURE OF LIFE
BIOS 100 NATURE OF LIFE
BIOS 731 SEMINAR IN MOLECULAR BIOLOGY
BIOS 731 SEMINAR IN MOLECULAR BIOLOGY
BIOS 711 THESIS

Fall 2015

BIOS 101 BIOSCIENCE
BIOS 499 INDEPENDENT STUDY
BIOS 453 MOL BIO/BIOINFRM NUCLEIC ACIDS
BIOS 653 MOL BIO/BIOINFRM NUCLEIC ACIDS
BIOS 489 MOLEC BIO/BIOINFRM SR PROJECT
BIOS 731 SEMINAR IN MOLECULAR BIOLOGY
BIOS 711 THESIS

Spring 2015

BIOS 301 CELL BIOLOGY
BIOS 301 CELL BIOLOGY
BIOS 711 THESIS

Fall 2014

BIOS 101 BIOSCIENCE
BIOS 453 MOL BIO/BIOINFRM NUCLEIC ACIDS
BIOS 653 MOL BIO/BIOINFRM NUCLEIC ACIDS
BIOS 711 THESIS

Spring 2014

BIOS 101 BIOSCIENCE
BIOS 499 INDEPENDENT STUDY
BIOS 711 THESIS

900 Wood Road · P.O. Box 2000 · Kenosha, WI 53141-2000 P 262-595-2345

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